|
KMID : 0043320180410020130
|
|
Archives of Pharmacal Research
2018 Volume.41 No. 2 p.130 ~ p.161
|
|
|
Protein tyrosine phosphatase 1B inhibitors from natural sources
|
|
Zhao Bing Tian
Nguyen Duc Hung
Le Duc Dat
Choi Jae-Sue
Min Byung-Sun
Woo Mi-Hee
|
|
|
Abstract
|
|
|
|
Since PTP1B enzyme was discovered in 1988, it has captured the research community’s attention. This landmark discovery has stimulated numerous research studies on a variety of human diseases, including cancer, inflammation, and diabetes. Tremendous progress has been made in finding PTP1B inhibitors and exploring PTP1B regulatory mechanisms. This review investigates for the natural PTP1B inhibitors, and focuses on the common characteristics of the discovered structures and structure?activity relationships. To facilitate understanding, all the natural compounds are here divided into five different classes (fatty acids, phenolics, terpenoids, steroids, and alkaloids), according to their skeletons. These PTP1B inhibitors of scaffold structures could serve as a theoretical basis for new concept drug discovery and design.
|
|
|
KEYWORD
|
|
|
PTP1B inhibitors, Natural sources, Chemical structure, Structure?activity relationships
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|
|